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According to the researchers, from medical institutions across China as well as the University of Cambridge and Harvard Medical School, constipation affects about 20% of the general population and about 70% of people in nursing homes, and most people with constipation (táo bón) are treated with one of two versions of over-the-counter laxatives (thuốc xổ).

The study, published Wednesday in the American Academy of Neurology’s medical journal, Neurology, suggests that a potential dementia link is strongest with osmotic laxatives, which draw water into stool to make it softer and easier to pass. The other major kind, stimulant laxatives, increases muscle contractions along the stool mass.

The study included about 10 years of self-reported data from 476,219 adults ages 40 and 69 in the UK. At the start, the study authors identified the participants’ health status and lifestyle factors, including their exposure to over-the-counter laxatives. About 3.6% of the participants reported using laxatives most days of the week for the previous four weeks.

These regular users were more likely to be women, have less education, have a chronic illness (ốm đau mạn tính), and regularly take anticholinergic (chống tác động kiểu colin) and opioid drugs. 

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